Set out this morning at 11 oClock was prevented seting out earlyer in consequence of two of my men geting drunk and absenting themselves. I f[i]nally found them and had them brought on board, so drunk that they were unable to help themselves passed several riffles and lay all night on the N. W. shore— [1] was here informed that there were some instances of the goitre in the neighbourhood two women who lived on the bank of the river just below they had emegrated to that place from the lower part of pensylvania and had contracted the disorder since there residence on the Ohio— The fever and ague and bilious fevers [2] here commence their banefull oppression and continue through the whole course of the river with increasing violence as your approach it's mouth— saw many squirrels this day swiming the river from N. W. to S. E. caught several by means of my dog—